Netflix renewed the series for a third and final season in July 2020. However, the season's shooting was pushed forward due to Christina Applegate's health issue. Filming commenced on May 7 2021, until April 25 2022.
Applegate, who was diagnosed with Multiple Sclerosis, told New York Times that Dead to Me's production was halted for almost five months when she began her treatment. She recalled feeling off-balance during the shooting before getting an official diagnosis while on the show's set.
The 49-year-old actress soldiered through when filming resumed, even being wheeled to the set and having her legs occasionally held off-camera. The crew also made changes to the script to work around her condition.
Applegate has since revealed on Twitter the challenges of living with MS, including sharing photos of the walking aides she uses and chronicling the disease’s resulting insomnia.
“Being technically disabled is what it is. I didn’t know what MS was before I had it. My life is changed forever,” she tweeted.