Emre Karayel's talents extended beyond television as he made his cinematic debut in the film 'Police' in 2006, directed by Onur Ünlü. This was followed by notable roles in films like 'Zincirbozan' (2007), 'Usta' (2008), and 'Başka Dilde Aşk' (2009). Karayel's commitment to social causes was also evident in his participation in the short film 'Ezber' (2009), which aimed to raise awareness about violence against stray animals.
Apart from his screen endeavors, Emre Karayel left a significant mark on the theater scene. His performances in plays like 'Testosterone,' 'Othello,' 'Ghetto,' and 'Azizname' showcased his versatility and earned him accolades, including the Most Successful Musical or Comedy Actor of the Year in a Supporting Role at the 13th Afife Theatre Awards.