Born in Cabra, Dublin, Gambon moved to London as a child and grew up in an Irish immigrant community in Camden. His journey into acting began after working as an apprentice toolmaker, eventually leading him to study at the Royal Academy of Dramatic Art. He made his professional stage debut in Dublin's Gate Theatre production of 'Othello' in 1962.
Gambon's talent and dedication to his craft caught the attention of the legendary actor Laurence Olivier, who invited him to join the newly-formed National Theatre Company. His career continued to flourish as he took on lead roles in Shakespearean plays.
However, it was in the 1980s that Gambon became a household name, earning widespread recognition for his portrayal of Philip Marlow in the Anglo-American television mini-series 'The Singing Detective.' He received numerous accolades for his contributions to drama, including being appointed Commander of the Order of the British Empire in 1990 and being knighted as a Knight Bachelor in 1998.