Even as a conservatory student, Öykü Karayel demonstrated her potential by auditioning for the play 'Güzel Şeyler Bizim Tarafta' by Krek. Impressively, she won the role of Ayşe among 30 other candidates. This professional debut earned her recognition and accolades, including the Efes Special Award and the Theater Critics Association Young Talent Award at the 16th Sadri Alışık Cinema and Theater Awards.
Her outstanding performance in the play caught the attention of screenwriter Ece Yörenç and producer Kerem Çatay, leading to her entry into the television industry. She portrayed the character Cemre Çayak in the TV series 'Kuzey Güney' and went on to appear in popular shows such as 'Kara Para Aşk,' 'Muhteşem Yüzyıl Kösem,' 'Kalp Atışı,' and 'Muhteşem İkili.'