José Zúñiga as Amilcar: Zúñiga portrays Amilcar, a prominent drug lord in Miami, adding a layer of intrigue and competition to the series.
Jose Velazquez as Uber: Uber, Griselda's second son, is portrayed by Jose Velazquez. His character's journey and interactions with Griselda add emotional depth to the storyline.
Orlando Pineda as Dixon: Griselda's oldest son, Dixon, is brought to life by Orlando Pineda. The portrayal of family dynamics within the criminal empire adds a compelling element to the series.
Martin Fajardo as Ozzy: Ozzy, Griselda's third son, played by Martin Fajardo, navigates the challenges of growing up in the shadow of a notorious mother. Fajardo's performance captures the complexities of familial ties amidst a life of crime.
Fredy Yate as Chucho Castro: Fredy Yate embodies Chucho Castro, a worker hired by Griselda as her bodyguard. Chucho's character adds an element of protection and loyalty within Griselda's inner circle.
Camilo Jiménez Varón as Rafa Salazar: Rafa Salazar, portrayed by Camilo Jiménez Varón, contributes to the intricate plotline as part of Griselda's world.
Diego Trujillo as German Panesso: The character German Panesso, played by Diego Trujillo, adds depth as a rival Colombian trafficker, showcasing the broader landscape of the drug trade.
Maximiliano Hernández as Papo Mejia: Papo Mejia, portrayed by Maximiliano Hernández, emerges as a rival Colombian trafficker, creating tension and conflict within Griselda's world.
Michael Reilly Burke as Captain Sweetwater: Michael Reilly Burke takes on the role of Captain Sweetwater, providing a glimpse into the law enforcement side of the narrative.
Carolina Giraldo as Carla: Carla, portrayed by Carolina Giraldo, serves as Griselda's friend and confidante, adding a layer of personal connection amidst the criminal landscape.
Paulina Dávila as Isabel: Isabel, portrayed by Paulina Dávila, contributes to the emotional depth of Griselda's character as a close friend from Medellín.
Alejandro Barrios as Horatio, Gabriel Sloyer as Raul Diaz, and Julieth Restrepo as Marta Ochoa: These recurring characters, played by Alejandro Barrios, Gabriel Sloyer, and Julieth Restrepo, respectively, add richness to the narrative, each contributing in their unique way.